Escitalopram Targets Oxidative Stress, Caspase-3, BDNF and MeCP2 in the Hippocampus and Frontal Cortex of a Rat Model of Depression Induced by Chronic Unpredictable Mild Stress.

The stress group had also increased MDA in the frontal cortex in comparison with controls, but the differences did not reach statistical significance (1.17 ± 0.24 vs. 0.86 ± 0.20, p > 0.05) ( Figure 4 B).

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Also, catalase activity showed a trend to increase in both examined brain areas after chronic stress and this may be in response to the intensification of oxidative stress.

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