Cognitively unimpaired individuals with a low burden of Aβ pathology have a distinct CSF biomarker profile.

In the analyses including the extreme values ( Table S2 in Additional file), the significant increase in CSF NfL in the low burden group in definition 1 was lost ( P = 0.051). In definition 2, CSF neurogranin and NfL also showed a trend to increased values in the low burden group, but did not reach statistical significance ( P = 0.081 and P = 0.080 for CSF neurogranin and NfL, respectively) (Table 3 , Fig. 1 ).

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Similarly, we observed a slight trend to an increased glucose metabolism, especially in the angular gyrus, associated to Aβ pathology.

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