Shotgun lipidomics of liver and brain tissue of Alzheimer's disease model mice treated with acitretin.

Notably, the observed shifts in down- and upregulated parameters were highly significant for both, brain and liver tissue ( p ≤ 0.001) (Fig. 2 C), and highly significant changes exist by comparing brain with liver tissue utilizing the Fisher ́s exact test.

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4 A); 40 out of them showed a strong trend out of the SEM.

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In liver tissue, 178 parameters tended to increase, whereas only 93 parameters showed a trend to be decreased upon acitretin treatment (Fig. 2 B).

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