Four proteins that were clearly significant at time point 1 but that did not pass the significance threshold at time point 2, and are of particular interest were FN1 ( P -value at t1: 4.82 × 10 −3 ; t2: 1.61 × 10 −1 ; t3: 4.37 × 10 −1 ), IGHA1 ( P -value at t1: 2.45 × 10 −3 ; t2: 1.21 × 10 −1 ; t3: 2.67 × 10 −1 ), IGHA2 ( P -value at t1: 1.11 × 10 −2 ; t2: 7.9 × 10 −1 ; t3: 1.25 × 10 −1 ), and KNG1 ( P -value at t1: 2.67 × 10 −3 ; t2: 8.29 × 10 −2 ; t3: 5.68 × 10 −1 ).
← all excerpts
A serum proteome signature to predict mortality in severe COVID-19 patients.
3
—
—
The sentences
In sharp contrast, the abundance levels of ITIH3 and ITIH4 (that do not form a complex) show a decreasing trend during disease progression, and moreover these proteins are, although just below our statistical cutoff, consistently lower in abundance in survivors than in non-survivors.
These included the phosphatidylcholine-sterol acyltransferase (LCAT), an enzyme involved in the extracellular metabolism of plasma lipoproteins, which showed a trend similar to ITIH1 and ITIH2, consistently higher in survivors than in non-survivors and increasing in abundance during disease progression, both in the survivors and non-survivors.