Immunisation of ferrets and mice with recombinant SARS-CoV-2 spike protein formulated with Advax-SM adjuvant protects against COVID-19 infection.

Ferrets that received just a single vaccine dose similarly showed a trend toward higher interstitial pneumonia in the H&E staining and positive virus staining (Supplementary Fig. 5 B and 7Cxi) .

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There was also a clear trend to higher anti-spike CD4 T cell responses in mice that had received Advax-SM adjuvanted rSp, although this difference only reached significance in the BALB/c group ( Fig. 6 ) . 3.4.

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