Functional Dynamics of Deafferented Early Visual Cortex in Glaucoma.

In fact, the differential activation (reflected by Cohen’s d) we observed in V1 was not exceeded by those in V2 and V3 and did not reach statistical significance in a respective ANOVA.

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Nonetheless, based on the magnitude of R 2 , a negative trend in the task-effect with both MD (V1: 0.29; V2: 0.49) and the percentage of VF loss (V1: 0.18; V2: 0.38) in V1 and V2 was indicated, but not for V3.

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This effect was also significant in glaucoma V3 ( t = 10.2; p = 0.006), while the same trend in V2 ( t = 2.8; p = 0.069) failed to reach significance ( Figures 2B,C ).

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While there was an overall trend for smaller cortical thickness in the patient group [cortical thickness controls vs. patients (mm) mean ± SEM: 1.76 ± 0.03 vs. 1.65 ± 0.02 (V1); 1.99 ± 0.05 vs. 1.93 ± 0.05 (V2); 2.31 ± 0.07 vs. 2.08 ± 0.05 (V3)], this did not reach significance.

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