High-fat diet-induced diabetes leads to vascular alterations, pericyte reduction, and perivascular depletion of microglia in a 6-OHDA toxin model of Parkinson disease.

However, HFD significantly aggravated the motor performance in the cylinder test and showed a trend toward higher rotations in amphetamine-induced rotations, indicating an imbalance of dopamine release between the lesioned and intact side of the brain [ 34 ].

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There was a clear trend toward worse performance in amphetamine-induced rotations of both lesioned groups when on HFD compared to when on CTRL diet; however, this did not reach significance ( p = 0.14, p = 0.21, respectively) (Fig. 4 A, B).

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