The molecular basis, genetic control and pleiotropic effects of local gene co-expression.

eQTL sharing : Whether the lead cis-eQTL (FDR 5%, Benjamini–Hochberg procedure) of one gene in the pair is nominally significant ( p -value < 0.05) for association with the other gene in the gene pair.

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9 ; see the “Methods” section), we observed a clear trend in which conserved COPs generally have higher AUCs across molecular features than tissue-specific or unique COPs (Supplementary Fig. 10 ).

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