Effect of adding hydrochlorothiazide to usual treatment of patients with acute decompensated heart failure: a randomized clinical trial.

In absolute values, there was an increase in creatinine with borderline significance (HCTZ: 0.50 ± 0.37 vs placebo: 0.27 ± 0.40; p = 0.05).

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Although the primary outcome reached borderline significance, a post hoc analysis adjusted to the dose of intravenous furosemide showed a statistically significant result, which is consistent with the hypothesis of synergy when adding HCTZ to furosemide, with a clinically relevant effect on daily weight loss.

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This result did not reach statistical significance.

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