Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicity.

J Neuroinflammation · 2021 · PMC8369722 · PMID 34399786

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did not reach statistical significanceP = 0.15not close (p > 0.1)

showed a trendno p-value reported

The analysis showed a trend toward higher levels of C1q in the putamen of individuals with MSA, where three MSA patients exhibited high C1q levels compared to neurological healthy individuals, but it did not reach statistical significance ( P = 0.15).

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