S100A8/A9 is not essential for the development of inflammation and joint pathology in interleukin-1 receptor antagonist knockout mice.

4 B). The absence of S100A8/A9 does not affect cartilage proteoglycan depletion, cartilage erosion, and bone erosion in ankle joints of Il-1rn −/− during late arthritis Overall, although not significantly increased, 12-week-old Il1rn −/− X S100a9 −/− mice consistently showed a trend towards increased bone and cartilage erosion and showed increased numbers of pro-inflammatory Ly6C high cells in the bone marrow and spleen.

also in 53,322 other papers

Although a trend towards increased numbers of neutrophils, Ly6C high monocytes, and CD11b neg/low Ly6C high osteoclast progenitors and a negative trend for Ly6C low monocytes could be observed in the Il1rn −/− X S100a9 −/− mice compared to Il1rn −/− mice, this did not reach significance for any of these populations.

also in 4,201 other papers