Finally, another large study showed a trend toward improved survival with the use of PE in critically ill COVID-19 patients with features of a hyperinflammatory syndrome but did not reach statistical significance ( 35 ).
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Plasma Exchange in Patients With Severe Coronavirus Disease 2019: A Single-Center Experience.
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The sentences
Only an improvement in body temperature and CRP level was observed in the controls; the latter, however, did not reach statistical significance.