SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures.

A clear trend toward cytotoxicity was observed after 12 but not 6 d with αSyn 3K ( Fig. 1 B ).

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In a similar neuroblastoma model it was found that αSyn 3K protein levels were unchanged up to 10 μ m SCD inhibitor concentrations, although the CAY inhibitor showed a trend of protein lowering ( Imberdis et al., 2019 ).

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