The Cx43 Carboxyl-Terminal Mimetic Peptide αCT1 Protects Endothelial Barrier Function in a ZO1 Binding-Competent Manner.

Changes in the distribution of Cx43 and ZO1 induced by thrombin alone did not reach statistical significance at any sub-region within HDMECs ( Figure 8 C–F, Supplemental Table S2 ).

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While at first glance, it may appear that αCT1-I, in addition to αCT1 exhibits an increase in Cx43 at cell–cell borders, αCT1-I showed much more variability in its response than did αCT1 (see standard errors bars for αCT1-I (purple) in Figure 8 E and thus failed to reach statistical significance compared to thrombin treatment alone.

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