37 However, there was a high number of patients with stage IV, with a substantial percentage of patients being given mitotane along with chemotherapy, and while in fact an adverse trend was shown with inferior RFS for the mitotane group, OS appeared partly positively influenced.
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In addition, the OS did not reach statistical significance with 14.8 versus 12 months (HR 0.79, 95% CI 0.61–1.02), but there was a crossover integrated in the protocol, so a total of 101 patients received second line therapy with EDP-M, resulting in a similar outcome to first line of 5.6 months PFS.