Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity.

4 E), while the difference between genotypes in female mice just failed to reach significance ( Nnat + / + vs Nnat + /−p : P value females 0.08, Fig. 4 F).

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5 B,D), while an increase that did not reach statistical significance was observed in males (Supplementary Fig. 5 A,C).

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Both dBW and BW were highly significant predictors of EE.

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In both sexes, there was an increase in mean fat mass in Nnat + /−p mice compared to their Nnat + / + counterparts, though it failed to reach statistical significance in the males ( Nnat + / + vs Nnat + /−p : P value males = 0.14; P value females = 0.03) (Fig. 4 A,B).

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