Treatment potential of LPCN 1144 on liver health and metabolic regulation in a non-genomic, high fat diet induced NASH rabbit model.

J Endocrinol Invest · 2021 · PMC8421272 · PMID 33586025

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0010

boldest claim

The sentences

highly significantp < 0.001actually significant

6 c, which reports the highly significant correlation ( r = 0.853; p < 0.001) between the clinical score and the percentage of fibrosis of the sampled area in animals from all groups.

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a clear trendno p-value reported

HFD feeding also induced a significant increase in mRNA expression of several key pro-inflammatory genes (including CD68, GATA3, LOX1, TLR2, TLR4), while the two 1144 treatments showed a clear trend toward a reduction in their expression, as well as an improvement for pro- (CD11c) and anti-inflammatory (CD206) macrophage markers (M1 and M2 subtypes, respectively) (Table 4 ).

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did not reach statistical significanceno p-value reported

However, these differences did not reach statistical significance (Table 3 ).

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