A Water-free 0.1% Cyclosporine A Solution for Treatment of Dry Eye Disease: Results of the Randomized Phase 2B/3 ESSENCE Study.

Cornea · 2021 · PMC8423142 · PMID 34481407

Europe PMC DOI

hedged sentences

0.0844

closest p · 1.7× alpha

0.2634

boldest claim

The sentences

approached significanceP = 0.0844so close (0.05 < p ≤ 0.1)

This difference approached significance at week 2 and week 12 (Fisher exact test: P = 0.0844 and P = 0.0690, respectively).

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did not reach statistical significanceP = 0.2634not close (p > 0.1)

This improvement in total OSDI score of the CyclASol 0.1% group did not reach statistical significance compared with that of the vehicle group ( P = 0.2634) at week 4 in the primary analysis for this hierarchically tested endpoint.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.