Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa.

Analogous tests in mouse photoreceptor cell cultures showed a trend toward enhanced survival effects of paired leads but no fully additive effects ( Figure 4—figure supplement 2 ).

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In addition, the enhanced survival effects observed for paired compounds did not reach statistical significance relative to single compound controls after corrections for multiple comparisons.

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