Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice.

A lesser but still highly significant microglial depletion was observed in the subiculum of PLX3397-treated 5XFAD mice (62%; Fig. 1 b, d, S3A), a region of early plaque formation and high plaque density.

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An analysis in the subiculum again revealed a less robust effect, with a 40% decrease in microglia surrounding plaques that did not reach statistical significance (Fig. 2 d).

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Interestingly, the integrated APP value per plaque showed a trend toward reduction in PLX3397-treated 5XFAD mice compared to the control 5XFAD mice (Fig. 6 a, b).

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