Deletion of <i>Cdk5</i> in Macrophages Ameliorates Anti-Inflammatory Response during Endotoxemia through Induction of C-Maf and Il-10.

Il-12 mRNA expression was significantly reduced, and Il-12 protein showed a strong trend of reduction in Cdk5 LysMCre macrophages compared with macrophages isolated from Cdk5 flox mice after LPS stimulation ( Figure 1 D, Supplementary Figure S1C ).

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In addition, plasma Il-10 levels of Cdk5 LysMCre were significantly elevated 4 h after LPS injection and showed a trend toward increased plasma Il-10 levels at 2 h and 24 h of LPS-induced endotoxemia compared with their Cdk5 flox littermates ( Figure 4 A).

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