Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study.

Acta Neuropathol Commun · 2021 · PMC8442328 · PMID 34526147

Europe PMC DOI

hedged sentences

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closest p · 1.0× alpha

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boldest claim

The sentences

failed to reach statistical significancep < 0.05actually significant

Additionally, LATE-NC-by-SNV interaction terms were tests for models of HS and were removed if they failed to reach statistical significance (p < 0.05).

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nominally significantno p-value reported

A study analyzing gene-based associations between the GRN , TMEM106B , ABCC9 , and KCNMB2 genes and HS found Bonferroni-corrected significant associations for ABCC9 assuming a recessive mode of inheritance (MOI) and nominally significant associations with GRN , TMEM106B , and KCNMB2 [ 29 ].

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