Prolonged PCR positivity in elderly patients infected with SARS-CoV-2.

9 In patients with prolonged PCR positivity of at least 2 weeks from symptom onset, a significant trend in Ct toward higher values was seen with increasing time from symptom onset ( Fig. 1 ).

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These results, from a large cohort comprising hospitalised and non-hospitalised patients, are consistent with data from symptomatic non-hospitalised patients which also showed a trend toward higher Ct values over time. 11 As PCR assays cannot distinguish between nucleic acid detected from replicating virus and incomplete viral genetic fragments, prolonged PCR positivity may be expected beyond the acute infectious period.

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