HGF expression may be correlated with cancer cell metastasis and infiltration but the latter did not reach statistical significance.
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CABOCOL-01 trial: a single-arm phase II study assessing safety and efficacy of Cabozantinib for advanced or metastatic cervical carcinoma after platinum treatment failure.
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In CABOSUN and in METEOR trials evaluating Cabozantinib in metastatic renal cell carcinoma, MET surexpression assessed by immunochemistry showed a trend toward more benefit in MET-positive tumors but it was not statistically significant, even with combined data of both trials [ 19 – 21 ].