Genetic Polymorphisms, Gene-Gene Interactions and Neurologic Sequelae at Two Years Follow-Up in Newborns with Hypoxic-Ischemic Encephalopathy Treated with Hypothermia.

As nine SNPs were investigated, Bonferroni correction was used to account for multiple comparisons: p -values below 0.006 were considered statistically significant, while p -values between 0.006 and 0.050 were considered nominally significant.

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The CTG haplotype carrying less frequent IL1B rs1143623 C and IL1B rs16944 T alleles was more frequent in patients with epilepsy (OR =2.51 95% CI = 0.70–8.96; p = 0.156) and CP (OR =3.53 95% CI = 0.89–13.99; p = 0.072) compared to the reference GCC haplotype, but the difference did not reach statistical significance. 3.2.

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