Endothelial-Derived Extracellular Vesicles Induce Cerebrovascular Dysfunction in Inflammation.

Pharmaceutics · 2021 · PMC8472224 · PMID 34575601

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.4900

boldest claim

The sentences

a strong trendp = 0.054so close (0.05 < p ≤ 0.1)

We also investigated the relative levels of mRNAs that are directly involved in T-cell adhesion and observed that ICAM1 mRNA was significantly increased in cytokine-sEVs (6.21 ± 2.29, p = 0.017), whereas VCAM1 mRNA showed a strong trend (3.77 ± 1.62, p = 0.054) ( Figure 5 c).

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showed a trendp = 0.49not close (p > 0.1)

The anti-inflammatory miRNA-126-3p showed a trend towards downregulation in cytokine-sEVs (0.75 ± 0.56-fold change, p = 0.49), but this was not statistically significant ( Figure 5 a).

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a small trendno p-value reported

This effect was transient, since a longer incubation only showed a small trend for increased para-cellular permeability. 3.4.

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