Multiparametric MRI of early tumor response to immune checkpoint blockade in metastatic melanoma.

Further analysis of the individual lesions showed a trend towards a higher level of tumor heterogeneity, as measured by K app , in the pseudoprogressive lesions throughout the first 12 weeks of treatment (baseline: 0.84; 3 weeks: 0.64; 12 weeks: 0.76) compared with the responding lesions (baseline: 0.59; 3 weeks: 0.54; 12 weeks: 0.56); although this did not reach statistical significance, it may reflect underlying immune cell infiltration or cell death over the course of treatment.

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