Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination.

According to our data on Figure 7, Phb1-SCKO mice treated with rapamycin from P20 to P40 showed a trend towards amelioration of axonal degeneration in tibial nerves at P40 as assessed in semithin sections.

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Similarly, we also identified a correlation between p-S6 and the presence of myelin ovoids ( Figure 4D and E ), and a greater proportion of the SCs containing myelin ovoids were also positive for p-S6, although this difference did not reach statistical significance ( Figure 4F ).

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