17β-Estradiol Regulates miR-9-5p and miR-9-3p Stability and Function in the Aged Female Rat Brain.

Our data herein showed that there was a clear trend for E 2 to decrease levels in the heavy polysome fractions, while increasing it in the light polysome fractions, when comparing the statistical median for REST, SIRT1, and IGF1R, similar to what we observed with SRSF2.

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Treatment with E 2 showed a trend, but was not statistically significant, towards decreasing miR-9-5p in the 40S ribosomal complex (i.e., fraction 3), which may partly account for its significantly increased shift in the heavier polysome fractions (i.e., fraction 10).

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