What's behind <sup>68</sup>Ga-PSMA-11 uptake in primary prostate cancer PET? Investigation of histopathological parameters and immunohistochemical PSMA expression patterns.

Eur J Nucl Med Mol Imaging · 2021 · PMC8484204 · PMID 34386839

Europe PMC DOI

hedged sentences

0.0810

closest p · 1.6× alpha

0.1100

boldest claim

The sentences

showed a trendp = 0.081so close (0.05 < p ≤ 0.1)

A correlation between WHO/ISUP grade groups and PSMA %neg did not reach significance but showed a trend towards lower grade groups associated with higher percentages of PSMA negative areas ( p = 0.081, Kruskal–Wallis test).

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a positive trendp = 0.11not close (p > 0.1)

did not reach statistical significanceno p-value reported

Interestingly, we found only a positive trend of cytoplasmic ( p = 0.11, Kruskal–Wallis test) and membranous ( p = 0.13, Mann–Whitney U test) PSMA expression levels correlating with PSMA-PET positivity, which did not reach statistical significance.

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