Barely Significant
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PERK in POMC neurons connects celastrol with metabolism.

JCI Insight · 2021 · PMC8492333 · PMID 34549728

Europe PMCDOI
2
hedged sentences
0.0800
closest p · 1.6× alpha
0.0800
boldest claim

The sentences

did not reach statistical significanceP = 0.08so close (0.05 < p ≤ 0.1)
Erdj4 and EDEM1 also trended toward an increase in expression; however, this trend did not reach statistical significance [ Erdj4 , t(9) = 1.998, P = 0.08; EDEM1 , t(9) = 1.149, P > 0.05, Figure 3 ].

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failed to reach statistical significanceno p-value reported
There was a trend toward leaner body weight in POMC-cre:PERK loxp/loxp mice on a chow diet when compared with that of littermate controls; however, cumulative changes in body weight failed to reach statistical significance ( Figure 1A ).

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