Maternal High-Fat Diet Programs Renal Peroxisomes and Activates NLRP3 Inflammasome-Mediated Pyroptosis in the Rat Fetus.

Effect of MHF on TECs in Fetus Q-PCR analysis revealed that most of the tested PEXs showed a trend for reduction in primary culture TECs with exposure to MHF, though only the expression differences of Pex1,3,5,7,16 were statistically significant.

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The qPCR analyses showed that the expression levels of NRF2 and associated downstream genes (ie, NQO1, HO-1, and glutathione reductase) tended to be enhanced, although the latter two did not reach statistical significance due to high individual variations ( Figure 6A and B ).

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