Utilisation of a second large cDNA microarray dataset including 306 AML cases, again showed no correlation between BIRC5 levels and OS, but high expression levels of BIRC5 correlated with worse survival in inv(16) patients ( p = 0.077) which was highly significant when datasets A and B were combined ( p = 0.001).
We found a trend between above median levels of BIRC5 being associated with improved overall survival (OS) but this did not reach statistical significance ( p = 0.077, Log-Rank).
However OS showed a trend with BIRC5 present calls ( Figure 6 Ai) while relapse/disease free survival was significantly associated with BIRC5 present calls ( Figure 6 Bi) although this association was not found in CBF patients when examined alone ( Figure 6 Aii,Bii).