Auditory discrimination and frequency modulation learning in schizophrenia patients: amphetamine within-subject dose response and time course.

Psychol Med · 2023 · PMC8514598 · PMID 33849683

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0600

boldest claim

The sentences

near-significantp < 0.054so close (0.05 < p ≤ 0.1)

For QuickSIN, AMPH-enhanced performance approached significance for the 2.5 mg dose ( p < 0.06; d = 0.79); non-parametric comparisons also detected a near-significant effect at the 5 mg dose ( p < 0.054).

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approached significancep < 0.06so close (0.05 < p ≤ 0.1)

For WIN, compared to placebo, AMPH enhanced 4 dB performance at 2.5 and 5 mg doses ( p 's < 0.012 and d = 1.29 for each), and this effect approached significance for 10 mg AMPH ( p < 0.06; d = 0.98); these results were confirmed using non-parametric analyses (Wilcoxon signed-rank test: p < 0.016, 0.014 and 0.085 for 2.5, 5 and 10 mg AMPH v. placebo, respectively).

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