Anti-GD2 CAR MSCs against metastatic Ewing's sarcoma.

Transl Oncol · 2022 · PMC8517927 · PMID 34649148

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0700

boldest claim

The sentences

failed to reach significancep > .05actually significant

BF MSC fluorescence showed a tendency towards increasing in the liver compared with the 4 h but failed to reach significance ( p > .05; not shown).

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approached significancep = .053so close (0.05 < p ≤ 0.1)

The overall trend observed for the lungs was similar to that seen after 4 h, with the BF MSC signal remaining higher than the sTRAIL MSC one, which approached significance ( p = .053; data not shown).

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close to borderline significancep = .070so close (0.05 < p ≤ 0.1)

failed to achieve significancep = .070so close (0.05 < p ≤ 0.1)

When examining the liver, we observed a modest antitumour effect in the BF MSC group, which failed to achieve significance compared with the CTR [1.375 (1.037 to 2.561) vs 2.610 (1.751 to 4.075), 0.5-fold change; close to borderline significance ( p = .070)], EV MSC [1.375 (1.037 to 2.561) vs 2.915 (1.276 to 3.633), 0.6-fold change; p > .05], or GD2 tCAR MSC [1.375 (1.037 to 2.561) vs 2.318 (1.182 to 3.202), 0.6-fold change; p > .05] groups ( Fig. 6 c).

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did not achieve significanceno p-value reported

Liver metastases in BF MSC-treated mice were reduced by 40% compared with sTRAIL MSC-treated mice, although this difference did not achieve significance.

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