Mislocalization of Nucleocytoplasmic Transport Proteins in Human Huntington's Disease PSC-Derived Striatal Neurons.

However this reduction in gene expression IsoHD 30Q, was not mirrored by a significant decrease in lamin-B1 protein, though it showed a trend in the same direction; no changes in lamin-B1 protein were observed in ASO-treated IsoHD 81Q neurons ( Supplementary Figure 7 ).

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In the IsoHD lines, although a trend toward reduction of the N/C ratio was observed in the 81Q neurones, it did not reach statistical significance ( Figure 2G ).

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