Shared Genetics Between Age at Menopause, Early Menopause, POI and Other Traits.

Indeed, we observed overlapping signals between ANM SNPs and proxies (r 2 > 0.5) and SNPs influencing lipid levels, including genetic variants in STARD3, and the cross-trait LD score regression was nominally significant for HDL levels ( Teslovich et al., 2010 ; Day et al., 2015 ).

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Indeed, while cross-trait LD Score regression did showed a negative genetic correlation between ANM and fracture risk, upon correction for multiple testing this failed to reach significance ( Trajanoska et al., 2018 ).

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MR analysis based on 35 ANM SNPs showed a trend in causal inference with epithelial ovarian cancer risk ( Yarmolinsky et al., 2019 ).

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