A Novel Calpain Inhibitor Compound Has Protective Effects on a Zebrafish Model of Spinocerebellar Ataxia Type 3.

Cells · 2021 · PMC8533844 · PMID 34685571

Europe PMC DOI

hedged sentences

0.0531

closest p · 1.1× alpha

0.0553

boldest claim

The sentences

did not reach statistical significancep = 0.0531so close (0.05 < p ≤ 0.1)

Whilst treatment with 150 nM BLD-2736 yielded an improvement in the mean relative distance swum, direct comparison of this dose with vehicle treatment did not reach statistical significance ( p = 0.0531). 3.2.

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failed to reach statistical significancep = 0.0553so close (0.05 < p ≤ 0.1)

Interestingly, treatment with 150 nM BLD-2736 reduced the mean relative amount of cleaved ataxin-3 species when compared to vehicle treated controls, however, this comparison failed to reach statistical significance ( p = 0.0553). 3.3.

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