The S Protein of Group B <i>Streptococcus</i> Is a Critical Virulence Determinant That Impacts the Cell Surface Virulome.

A clear trend that emerged from this analysis was the increased number of significantly altered proteins for the S protein deletion mutant-infected animals (51 proteins) compared to the WT GBS infected animals (27 proteins) ( Figures 6C,D ).

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CFU enumeration of recovered brains revealed significantly lower bacterial levels in the Δ ess mutant strain-infected mice compared to the WT strain, with the revertant strain yielding an intermediate phenotype ( Figure 5G ) that did not reach statistical significance ( Doran et al., 2005 ; van Sorge et al., 2009 ; Banerjee et al., 2011 ).

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