IL-1beta promotes the age-associated decline of beta cell function.

Il1b and Il1rn expression were significantly increased in islet immune cells with age, whereas Il1r1 and Il1a showed a trend toward an increase.

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IL-1beta ko mice had a higher percentage of islets with one or more beta cell(s) with nuclear Ki67 staining ( Figure 4 J), and the proportion of Ki67 + ins + cells was also higher when normalized to the mean islet area, although this did not reach statistical significance ( Figure 4 K).

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