Sentinel Lymph Node in Aged Endometrial Cancer Patients "The SAGE Study": A Multicenter Experience.

Among the considered variables: age, non-endometrioid histotype, and LVSI appeared to be significantly correlated with mapping failure at univariate analysis, while BMI showed a strong trend towards significance (age ≥ 65 OR: 1.667, 95% CI: 1.230–2259, p = 0.001; BMI per 1 unit-increase OR: 1.021, 95% CI: 1.000-1.044, p = 0.054; non-endometrioid histotype OR: 1.813, 95% CI: 1.218–2.700, p = 0.003; presence of LVSI OR: 1.492, 95% CI: 1.084-2.053, p = 0.014).

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Compared to patients in Group 1, women over 65 showed a trend toward undertreatment across all risk categories, even if only in high-risk tumors did the difference reach statistical significance ( p = 0.018).

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Multivariable model was constructed considering all features that were found statistically significant ( p < 0.05) or with a trend toward significance at the univariate analysis ( p < 0.10) as independent variables and the bilateral mapping (failure/success) as the dependent variable.

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