Oral rotavirus vaccine shedding as a marker of mucosal immunity.

A smaller proportion of children without fecal RVA shedding following the second Rotarix dose subsequently experienced an episode of RVA diarrhea (26%) compared to children who shed RVA in the stool (39%; RR 0.679, 95% CI 0.415–1.110; Table 1 ), although this did not reach statistical significance.

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In summary, infants in Dhaka, Bangladesh who inhibited fecal shedding of Rotarix, a live-attenuated, oral vaccine, following the second vaccine dose demonstrated a clear trend towards reduced risk for subsequent RVA diarrhea through 2 years of life.

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