Aged IRF3-KO Mice are Protected from Sepsis.

Among the male mice, we observed a clear trend towards decreased CK in IRF3-KO mice vs WT mice subject to CLP ( Figure 3C ), but this difference was not statistically significant.

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Interestingly, aged male WT mice showed a trend towards lower levels of serum cytokines ( Figure 2D – F ) compared to their female counterparts ( Figure 2G – I ).

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