Metformin and Bone Metabolism in Endogenous Glucocorticoid Excess: An Exploratory Study.

Compared to CS-NOMET group, metformin-treated patients showed a reduction in body fat percentage following remission that was borderline significant ( p = 0.050, Table 2 ).

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Despite a more pronounced hyperglycemic state ( Supplementary Table 1 ), patients with metformin in our study showed a trend to less muscular impairment in grip strength during hypercortisolism ( Table 2 ).

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Differences in muscle function measured by grip strength did not reach statistical significance.

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