(R,S)-ketamine and (2R,6R)-hydroxynorketamine differentially affect memory as a function of dosing frequency.

Transl Psychiatry · 2021 · PMC8590048 · PMID 34772915

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hedged sentences

0.0806

closest p · 1.6× alpha

0.2630

boldest claim

The sentences

near-significantP = 0.0806so close (0.05 < p ≤ 0.1)

Deficits in novel object recognition were further evidenced as a near-significant reduction in discrimination index scores with regard to the main effect of treatment (Fig. 3E ; F (4,75) = 2.169, P = 0.0806).

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did not reach statistical significanceP = 0.2630not close (p > 0.1)

The main effect of treatment on discrimination index did not reach statistical significance (Fig. 4E ; F (4,65) = 1.344, P = 0.2630) though similar to adolescent-treated mice, the mean discrimination index was numerically lower for mice treated thrice-weekly with ketamine or with daily ( 2R,6R )-HNK compared to control mice.

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