CXCR7 Antagonism Reduces Acute Lung Injury Pathogenesis.

In the BAL from LPS-challenged mice, treatment with ACT-1004-1239 significantly reduced LPS-induced CXCR3 + lymphoid cell recruitment ( Figure 3C ) and showed a trend to decrease the late recruitment of the few CXCR3 + myeloid cells induced by LPS, although this did not reach statistical significance ( Figure 3D ).

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