Subclinical cardiovascular disease and utility of coronary artery calcium score.

sociated with FGF-21 (excepts CRP, Fibrinogen and IL-6) and again in further fully-adjusted model 3 (model 2 + CRP, Fibrinogen and IL-6); furthermore, non-linearly for FGF-21 ≥ 80.0 mg/dL FGF-21 level to CVD endpoints significantly associated with hard CVD in model 1 (HR:1.34, 95% CI:1.12–1.60) and borderline significance in model 2 (HR:1.20, 95% CI:1.00–1.45) besides hard CHD in model 1 (HR:1.46, 95% CI:1.19–1.80) and model 2 (HR:1.26, p = 0.045) yet in model 3 no significant association was observed for both end-points.

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r medication, dyslipidemia or medication, diabetes or medication, fasting blood glucose, HbA1c ≥ 6.5%, eGFR < 60 mL/min/1.73 m 2 , uric acid ≥ 7.1 mg/dl, metabolic syndrome, smoking history and alcohol consumption by ≥ 20 g/day significantly associated yet in multivariate analysis of significant or near-significant (p < 0.2) covariates of univariate analysis only dyslipidemia (OR:1.74) and fasting glucose (1.01) along with aging per year (OR:1.10) and male gender (OR:2.46) remained significant with CACs > 100.

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[116] , recruiting almost half a million Chinese adults aged 30–79 years followed along period of median 8.9 years on ongoing China Kadoorie Biobank (CKB) cohort study, observed a significant trend of increasing egg consumption stratum, such as 1 egg each day compared to almost non-consuming per week, associates with lower risk of CVD (OR:0.89), ischaemic heart disease (IHD; OR:0.86), major caronary event (MCE; OR:0.74) and ischaemic stroke (OR:0.90); and similarly egg consumption strata inversely associated with lower mortality rates caused by CVD (OR:0.82) and haemorrhagic stroke (OR:0.72).

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A MESA study with median follow-up of 11.0 years, a total of 3398 participants free of clinical event, [47] according to Cox models fully adjusted for individual CVD risk factors, where hazard ratio represent 1 SD of the independent variable, demonstrated ln CAC volume score adjusted for CAC density was a highly significant predictor of CHD and CVD with HRs of 1.73 (CI: 1.45–2.05) and 1.61 (CI: 1.39–1.85), respectively; and CAC density adjusted for lnCAC volume score at each SD increase significantly associate with 28% (CI: 0.60–0.86) risk reduction for CHD and 25% (CI: 0.65–0.87) risk reduction for CVD.

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having previously diagnosed diabetes and poor glucose control (HbA1c ≥ 7.0) had significantly higher rate of rapid CACs progression over annual change of > 30% of baseline score (OR:2.3, 95% CI:1.4–23.7) compared to reference group of patients having no previous DM history and HbA1c < 5.7% yet only a nonsignificant trend of increased risk for participants with well controlled known diabetes history (HbA1c < 7.0%), similarly according to fully-adjusted linear regression model % change in geometric mean of PF5 (Progression Factor at 5‘th Year Examination), which is extrapolation of exponential model derived on age an

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