A Novel Cellular Therapy to Treat Pancreatic Pain in Experimental Chronic Pancreatitis Using Human Alpha-1 Antitrypsin Overexpressing Mesenchymal Stromal Cells.

Mice receiving hAAT-MSCs also showed a trend of reduced inflammation, necrosis, fibrosis, and interlobular edema ( Figure 2 B), which might have contributed to better preserved pancreases. 3.3.

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We could not definitively prove that hAAT-MSC infusions were more effective in reversing TNBS pancreatitis or pain compared to native MSCs in this study although a strong trend of better protection was observed in the hAAT-MSC group compared to the native MSC group ( Table S1 ).

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