Repurposing Disulfiram for Targeting of Glioblastoma Stem Cells: An In Vitro Study.

In addition, FBS “differentiation” was paralleled in LK7 by a downregulation of ALDH1A3 , SOX2 , MSI1 and FAPB7 mRNA and in LK17 cells by a decrease in NOTCH1 , SOX2 , MSI1 , PROM1 and FABP7 (the latter two did not reach statistical significance) as well in an increase of ALDH1A3 mRNA abundance ( Figure 1 E, compare open and closed columns).

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In LK17 cells, in sharp contrast, disulfiram/Cu 2+ treatment showed a trend ( p values between 0.12–0.21, two-tailed Welch-corrected t -test) to reduce abundances of all tested marker mRNAs except that of ALDH1A3 (the latter increased significantly at a very low level, Figure 2 B).

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