Pro-Inflammatory Serum Amyloid a Stimulates Renal Dysfunction and Enhances Atherosclerosis in Apo E-Deficient Mice.

Kidney tissue homogenates from mice administered SAA showed a ~2-fold increase in KIM-1 expression compared to the vehicle control, although this did not reach statistical significance ( Figure 3 A).

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Quantification of the in vivo bioluminescent signal (in the thoracic and lower gut regions) using Living Image ® (PerkinElmer) showed a trend towards increasing in mice administered SAA compared to the respective control, whereas the corresponding quantification of MMP activity in isolated kidneys showed a significant difference. 6.2.

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